DR MERCOLA - INFLAMATION
By Dr. Mercola
ABOUT 34 PERCENT OF AMERICANS HAVE METABOLIC SYNDROME, WHICH IS A TERM USED TO DESCRIBE A CLUSTER OF SYMPTOMS THAT INCREASES YOUR RISK OF HEART DISEASE, DIABETES, STROKE, AND OTHER CHRONIC DISEASE.
THOSE SYMPTOMS INCLUDE A LARGE WAISTLINE, HIGH BLOOD PRESSURE, HIGH BLOOD SUGAR, LOW LEVELS OF HDL CHOLESTEROL, AND HIGH LEVELS OF TRIGLYCERIDES. THOUGH THEY MAY SEEM, AT FIRST, TO BE VERY DIFFERENT SYMPTOMS.
THEY HAVE A COMMON UNDERLYING THREAD, AS DOES METABOLIC SYNDROME AND RELATED HEART DISEASE… IN A WORD “INFLAMMATION.” CHRONIC INFLAMMATION IS ASSOCIATED WITH METABOLIC SYNDROME, WITH RESEARCHERS IN ONE JOURNAL NOTING:
“IT HAS BECOME EVIDENT THAT THE INFLAMMATORY CONDITION THAT IS ASSOCIATED WITH OBESITY AND OVERWEIGHT PLAYS AN IMPORTANT PART IN THE AETIOLOGY OF THE METABOLIC SYNDROME AND LARGELY CONTRIBUTES TO THE RELATED PATHOLOGICAL OUTCOMES.”
IT MAKES SENSE, THEN, THAT CURCUMIN – ONE OF THE MOST POTENT ANTI-INFLAMMATORIES IN NATURE – WOULD ALSO HELP TO LOWER INFLAMMATION IN PEOPLE WITH THE DISORDER.
DAILY CURCUMIN LOWERS INFLAMMATION AND BLOOD SUGAR LEVELS IN PEOPLE
RESEARCHERS ENROLLED 117 PEOPLE DIAGNOSED WITH METABOLIC SYNDROME IN A STUDY TO DETERMINE CURCUMIN’S EFFECTS ON INFLAMMATION. CURCUMIN IS THE ACTIVE INGREDIENT IN THE YELLOW CURRY SPICE TURMERIC. HALF OF THE PARTICIPANTS TOOK ONE GRAM OF CURCUMIN POWDER DAILY FOR EIGHT WEEKS WHILE THE OTHER HALF RECEIVED A PLACEBO PILL.
AT THE END OF THE STUDY, THE CURCUMIN GROUP HAD LOWER LEVELS OF THREE BLOOD MARKERS OF INFLAMMATION, INCLUDING C-REACTIVE PROTEIN (CRP), ALONG WITH LOWER FASTING BLOOD SUGAR AND HEMOGLOBIN A1C (A MEASURE OF LONGER TERM BLOOD SUGAR LEVELS).
FOR COMPARISON, THE PLACEBO GROUP HAD HIGHER BLOOD SUGAR LEVELS AND INCREASED INFLAMMATION AFTER THE EIGHT WEEKS. WHEN THE RESEARCHERS EVALUATED EIGHT PREVIOUS STUDIES, THEY, TOO, CONFIRMED THAT CURCUMIN LEAD TO REDUCTIONS IN CRP LEVELS.
THEY CONCLUDED THAT SHORT-TERM SUPPLEMENTATION WITH BIOAVAILABLE CURCUMIN SIGNIFICANTLY IMPROVES OXIDATIVE AND INFLAMMATORY STATUS IN PEOPLE WITH METABOLIC SYNDROME, AND COULD BE REGARDED AS A “NATURAL, SAFE AND EFFECTIVE CRP-LOWERING AGENT.”
CURCUMIN MAY HAVE OVER 150 THERAPEUTIC PROPERTIES
RESEARCHERS HAVE PREVIOUSLY INVESTIGATED CURCUMIN FOR ITS POTENTIAL ROLE IN IMPROVING PARKINSON'S, ALZHEIMER’S DISEASE, AND STROKE DAMAGE. IT CAN ALSO PROMOTE BRAIN HEALTH IN GENERAL, COURTESY OF ITS POTENT ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES – THE SAME ONES THAT SHOW PROMISE FOR IMPROVING METABOLIC SYNDROME.
CURCUMIN EXHIBITS OVER 150 POTENTIALLY THERAPEUTIC ACTIVITIES, INCLUDING POTENT ANTI-CANCER PROPERTIES. CURCUMIN IS ALSO CAPABLE OF CROSSING YOUR BLOOD-BRAIN BARRIER, WHICH IS ONE REASON WHY IT HOLDS PROMISE AS A NEUROPROTECTIVE AGENT IN A WIDE RANGE OF NEUROLOGICAL DISORDERS.
ONE OF THE WAYS IT WORKS, WHICH IS SIMILAR TO VITAMIN D, IS BY MODULATING LARGE NUMBERS OF YOUR GENES. PREVIOUS RESEARCH HAS ALSO DEMONSTRATED THAT CURCUMIN ACTS BY INSERTING ITSELF INTO YOUR CELLS' MEMBRANES WHERE IT CHANGES THE PHYSICAL PROPERTIES OF THE MEMBRANE ITSELF, MAKING IT MORE ORDERLY.
AS FOR ITS ANTI-INFLAMMATORY PROPERTIES, CURCUMIN CAN INHIBIT BOTH THE ACTIVITY AND THE SYNTHESIS OF CYCLOOXYGENASE-2 (COX2) AND 5-LIPOOXYGENASE (5-LOX), AS WELL AS OTHER ENZYMES THAT HAVE BEEN IMPLICATED IN INFLAMMATION.
A 2006 STUDY ALSO FOUND THAT A TURMERIC EXTRACT COMPOSED OF CURCUMINOIDS (CURCUMIN IS THE MOST INVESTIGATEDCURCUMINOID) BLOCKED INFLAMMATORY PATHWAYS, EFFECTIVELY PREVENTING THE LAUNCH OF A PROTEIN THAT TRIGGERS SWELLING AND PAIN.
IF YOU WANT TO TRY ONE HERB… TRY CURCUMIN
TURMERIC MAY VERY WELL BE ONE OF THE MOST USEFUL HERBS ON THE PLANET, AND IN INDIA IS OFTEN REFERRED TO AS “THE SPICE OF LIFE.” CURCUMIN IN TURMERIC HAS THE ABILITY TO MODULATE GENETIC ACTIVITY AND EXPRESSION—BOTH BY DESTROYING CANCER CELLS AND BY PROMOTING HEALTHY CELL FUNCTION.
IT ALSO PROMOTES ANTI-ANGIOGENESIS, MEANING IT HELPS PREVENT THE DEVELOPMENT OF ADDITIONAL BLOOD SUPPLY NECESSARY FOR CANCER CELL GROWTH. CURCUMIN APPEARS TO BE UNIVERSALLY USEFUL FOR JUST ABOUT EVERY TYPE OF CANCER. IN ADDITION, ACCORDING TO AN EVER-EXPANDING CLINICAL BODY OF STUDIES, CURCUMIN MAY HELP:
SUPPORT HEALTHY CHOLESTEROL LEVELS
PREVENT LOW-DENSITY LIPOPROTEIN OXIDATION
INHIBIT PLATELET AGGREGATION
SUPPRESS THROMBOSIS AND MYOCARDIAL INFARCTION
SUPPRESS SYMPTOMS ASSOCIATED WITH TYPE 2 DIABETES
SUPPRESS SYMPTOMS OF RHEUMATOID ARTHRITIS
SUPPRESS SYMPTOMS OF MULTIPLE SCLEROSIS
SUPPRESS SYMPTOMS OF ALZHEIMER'S DISEASE
INHIBIT HIV REPLICATION
SUPPRESS TUMOR FORMATION
ENHANCE WOUND HEALING
PROTECT AGAINST LIVER DAMAGE
INCREASE BILE SECRETION
PROTECT AGAINST CATARACTS
PROTECT AGAINST PULMONARY TOXICITY AND FIBROSIS
A STUDY PUBLISHED IN NATURAL PRODUCT REPORTS IN 2011 MAKES IT EVEN CLEARER WHY CURCUMIN MAY BE USEFUL FOR THE CLUSTER OF CONDITIONS THAT MAKE UP METABOLIC SYNDROME, AS IT DESCRIBES CURCUMIN AS BEING THERAPEUTIC FOR A WIDE RANGE OF DISEASES, INCLUDING:
LUNG AND LIVER DISEASES
WILL EATING TURMERIC PROVIDE THE SAME BENEFITS?
TURMERIC IS A WONDERFUL SPICE WITH A WARM EARTHY, PEPPERY FLAVOR. EASTERN CULTURAL TRADITIONS, INCLUDING TRADITIONAL CHINESE MEDICINE AND AYURVEDA, HAVE VALUED TURMERIC FOR ITS MEDICINAL PROPERTIES AND FLAVOR FOR MORE THAN 5,000 YEARS.
THIS IS ONE SPICE I RECOMMEND KEEPING IN YOUR KITCHEN AT ALL TIMES, AS IT WORKS WELL ADDED TO TOMATO SAUCES, SOUPS, STEWS, LEAFY GREENS, STIR FRIES, CAULIFLOWER AND OTHER VEGGIES, AND EVEN EGGS.
CHOOSING HIGH-QUALITY TURMERIC POWDER IN LIEU OF CURRY POWDER WILL HELP YOU GET MORE OF THE ACTIVE CURCUMIN, HOWEVER, IF YOU’RE LOOKING FOR THERAPEUTIC EFFECTS A SUPPLEMENT MAY BE IN ORDER.
IT’S DIFFICULT TO GET THE DOSES OF CURCUMIN USED IN RESEARCH STUDIES FROM YOUR DIET ALONE. THE FEATURED STUDY USED A DOSE OF ONE GRAM OF CURCUMIN, WHILE TYPICAL ANTI-CANCER DOSES ARE UP TO THREE GRAMS OF BIOAVAILABLE CURCUMIN EXTRACT, THREE TO FOUR TIMES DAILY, AND THIS IS DIFFICULT TO ACHIEVE USING STANDARD CURCUMIN POWDERS. THE TURMERIC ROOT ITSELF CONTAINS ONLY ABOUT 3 PERCENT CURCUMIN CONCENTRATION.
ONE METHOD TO INCREASE ABSORPTION IS TO MAKE A MICROEMULSION BY COMBINING A TABLESPOON OF CURCUMIN POWDER WITH 1-2 EGG YOLKS AND A TEASPOON OR TWO OF MELTED COCONUT OIL. THEN USE A HAND BLENDER ON HIGH SPEED TO EMULSIFY THE POWDER.
ANOTHER STRATEGY YOU CAN USE TO INCREASE ABSORPTION IS TO PUT ONE TABLESPOON OF THE CURCUMIN POWDER INTO A QUART OF BOILING WATER. IT MUST BE BOILING WHEN YOU ADD THE POWDER, AS IT WILL NOT WORK AS WELL IF YOU PUT IT IN ROOM TEMPERATURE WATER AND HEAT THE WATER AND CURCUMIN TOGETHER. AFTER BOILING IT FOR 10 MINUTES, YOU WILL HAVE CREATED A 12% SOLUTION AND YOU CAN DRINK THIS ONCE IT HAS COOLED DOWN. THE CURCUMIN WILL GRADUALLY FALL OUT OF THE SOLUTION OVER TIME AND IN ABOUT SIX HOURS IT WILL BE A 6% SOLUTION, SO IT IS BEST TO DRINK THE WATER WITHIN FOUR HOURS.
CURCUMIN IS A VERY POTENT YELLOW PIGMENT AND CAN PERMANENTLY DISCOLOR SURFACES IF YOU AREN'T CAREFUL. TO AVOID "YELLOW KITCHEN SYNDROME," I RECOMMEND YOU PERFORM ANY MIXING UNDER THE HOOD OF YOUR STOVE WITH THE BLOWER ON TO MAKE SURE NO POWDER GETS INTO YOUR KITCHEN. ALTERNATIVELY, IT IS FAR EASIER TO TAKE CURCUMIN IN SUPPLEMENT FORM – JUST MAKE SURE IT’S A HIGH-QUALITY BRAND THAT IS FORMULATED TO INCREASE BIOAVAILABILITY. AND LOOK FOR A TURMERIC EXTRACT WITH AT LEAST 95% CURCUMINOIDS. JUST BE AWARE THAT THESE ARE RELATIVELY RARE AND HARD TO FIND.
INSULIN RESISTANCE ALSO PLAYS A ROLE IN METABOLIC SYNDROME
IF YOU HAVE METABOLIC SYNDROME, YOU’RE MOST LIKELY INSULIN RESISTANT. ACCORDING TO DR. ROBERT LUSTIG, PROFESSOR OF PEDIATRIC ENDOCRINOLOGY AT THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (USCF), WHATEVER ORGAN BECOMES INSULIN RESISTANT ENDS UP MANIFESTING ITS OWN CHRONIC METABOLIC DISEASE. FOR EXAMPLE, WHEN YOU HAVE INSULIN RESISTANCE OF THE LIVER, YOU END UP WITH TYPE 2 DIABETES. WHEN YOU HAVE INSULIN RESISTANCE OF THE BRAIN, YOU END UP WITH ALZHEIMER’S DISEASE. INSULIN RESISTANCE OF THE KIDNEY LEADS TO CHRONIC RENAL DISEASE, AND SO FORTH. ALL OF THESE DISEASES ARE INSULIN-RESISTANT STATES. THE QUESTION IS WHAT CAUSES THE INSULIN RESISTANCE IN THE FIRST PLACE?
"[W]E HAVE SOME NEW DATA THAT WE ARE VERY EXCITED ABOUT, WHICH DEMONSTRATE THAT IF YOU OVERLOAD THE MITOCHONDRIA, THE LITTLE ENERGY-BURNING FACTORIES WITHIN CELLS, IN ANY GIVEN ORGAN, YOU'LL END UP MANIFESTING VARIOUS FORMS OF CHRONIC METABOLIC DISEASE," DR. LUSTIG SAYS. “THE CHEMICAL THAT OVERLOADS THE MITOCHONDRIA BEST IS TRANS-FATS. BUT THE CHEMICAL THAT OVERLOADS THE MITOCHONDRIA NEXT BEST IS SUGAR. TRANS FATS AND SUGAR PRETTY MUCH CHARACTERIZE THE PROCESSED FOOD DIET.”
EXCESSIVE DIETARY SUGAR, PARTICULARLY FRUCTOSE, WHICH HAS ADVERSE EFFECTS ON ALL OF YOUR METABOLIC HORMONES, IS DRIVING THE HIGH RATES OF INSULIN RESISTANCE IN THE US. SO IT'S IMPORTANT TO ADDRESS THE FRUCTOSE IN YOUR DIET, KEEPING IT BELOW 25 GRAMS PER DAY AND, IF YOU HAVE METABOLIC SYNDROME, BELOW 15 GRAMS A DAY. SIMPLY PUT, YOU’VE GOT TO CUT PROCESSED FOODS FROM YOUR DIET AND FOCUS ON REAL FOOD (WHICH, BENEFICIALLY, WILL ALSO HELP TO LOWER YOUR LEVELS OF CHRONIC INFLAMMATION). INTERMITTENT FASTING MAY BE ANOTHER WAY TO ADDRESS INSULIN RESISTANCE, AS IS EXERCISE.
EXERCISE IS CRUCIAL TO RESOLVING METABOLIC SYNDROME BECAUSE IT INCREASES MUSCLE MASS, WHICH INCREASES MITOCHONDRIA, AND THIS IN TURN IMPROVES INSULIN SENSITIVITY. ALSO IMPORTANT IS OPTIMIZING YOUR GUT FLORA, IDEALLY BY EATING TRADITIONALLY FERMENTED FOODS. KEEP IN MIND THAT PROCESSED FOODS IN GENERAL TEND TO DESTROY HEALTHY MICROFLORA, SO IF YOU SWITCH TO A LOW-SUGAR WHOLE-FOOD DIET YOU’LL AUTOMATICALLY BE SUPPORTING YOUR GUT HEALTH AS WELL. FOR MORE INFORMATION ON HOW OVERLOADING YOUR LIVER WITH MORE SUGAR THAN IT CAN SAFELY METABOLIZE LEADS TO CHRONIC METABOLIC DISEASE – AND WHAT TO DO ABOUT IT – PLEASE WATCH MY INTERVIEW WITH DR. LUSTIG BELOW.
MAYO CLINIC – CANCER
CAN CURCUMIN SLOW CANCER GROWTH?
Answers from Timothy J. Moynihan, M.D.
At this time, there isn't enough evidence to recommend curcumin for preventing or treating cancer, but research is ongoing.
Curcumin, a substance found in the spice turmeric, has long been used in Asian medicine to treat a variety of maladies. Now some research suggests that curcumin may help prevent or treat cancer.
Curcumin is thought to have antioxidant properties, which means it may decrease swelling and inflammation. It's being explored as a cancer treatment in part because inflammation appears to play a role in cancer.
Laboratory and animal research suggests that curcumin may prevent cancer, slow the spread of cancer, make chemotherapy more effective and protect healthy cells from damage by radiation therapy. Curcumin is being studied for use in many types of cancer.
Studies of curcumin in people are still in the early stages. Clinical trials are underway to investigate curcumin as a way to prevent cancer in people with precancerous conditions, as a cancer treatment, and as a remedy for signs and symptoms caused by cancer treatments.
Research is ongoing, and there isn't enough evidence to recommend curcumin at this time. As always, talk with your doctor before using any herbal supplement. It's unclear how curcumin may interact with medications.
Timothy J. Moynihan, M.D.
NATIONAL INSTITUTES OF HEALTH - PARKINSON'S DISEASE
CURCUMIN: A POTENTIAL NEUROPROTECTIVE AGENT IN PARKINSON'S DISEASE.
Mythri RB1, Bharath MM.
- 1Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore-560029, Karnataka, India.
Parkinson's disease (PD) is an age-associated neurodegenerative disease clinically characterized as a movement disorder. The motor symptoms in PD arise due to selective degeneration of dopaminergic neurons in the substantia nigra of the ventral midbrain thereby depleting the dopamine levels in the striatum. Most of the current pharmacotherapeutic approaches in PD are aimed at replenishing the striatal dopamine. Although these drugs provide symptomatic relief during early PD, many patients develop motor complications with long-term treatment. Further, PD medications do not effectively tackle tremor, postural instability and cognitive deficits. Most importantly, most of these drugs do not exhibit neuroprotective effects in patients. Consequently, novel therapies involving natural antioxidants and plant products/molecules with neuroprotective properties are being exploited for adjunctive therapy. Curcumin is a polyphenol and an active component of turmeric (Curcuma longa), a dietary spice used in Indian cuisine and medicine. Curcumin exhibits antioxidant, anti-inflammatory and anti-cancer properties, crosses the blood-brain barrier and is neuroprotective in neurological disorders. Several studies in different experimental models of PD strongly support the clinical application of curcumin in PD. The current review explores the therapeutic potential of curcumin in PD.
VANDERBILT UNIVERSITY - ALZHEIMER'S DISEASE
Vanderbilt investigators are studying curcumin, which is found in the spice turmeric, as a treatment for Alzheimer’s disease.
by Patricia Jumbo-Lucioni
One of the most promising new treatments for Alzheimer’s disease may already be in your kitchen. Curcumin, a natural product found in the spice turmeric, has been used by many Asian cultures for centuries, and a new study indicates a close chemical analog of curcumin has properties that may make it useful as a treatment for the brain disease.
“Curcumin has demonstrated ability to enter the brain, bind and destroy the beta-amyloid plaques present in Alzheimer’s with reduced toxicity,” said Wellington Pham, Ph.D., assistant professor of Radiology and Radiological Sciences and Biomedical Engineering at Vanderbilt and senior author of the study, published recently in the Journal of Alzheimer’s Disease.
Accumulation and aggregation of protein fragments, known as beta-amyloid, drives the irreversible loss of neurons in Alzheimer’s disease.
Developing small molecules to reduce this accumulation or promote its demolition is crucial, but the ability of these small molecules to cross the blood-brain barrier has been a restricting factor for drug delivery into the brain.
Pham and colleagues at Shiga University of Medical Science in Otsu, Japan, developed a new strategy to deliver a molecule similar to curcumin more effectively to the brain.
“One of the difficulties in the treatment of Alzheimer’s disease is how to deliver drugs across the blood brain barrier,” he said. “Our body has designed this barrier to protect the brain from any toxic molecules that can cross into the brain and harm neurons.
“But it is also a natural barrier for molecules designed for disease-modifying therapy,” Pham said.
To work around the problems of giving the drug intravenously, the researchers decided to develop an atomizer to generate a curcumin aerosol. The Japanese researchers developed a molecule similar to curcumin, FMeC1, which was the one actually used in this study.
“The advantage of the FMeC1 is that it is a perfluoro compound, which can be tracked by the biodistribution in the brain noninvasively using magnetic resonance imaging. Curcumin is a very simple chemical structure, so it is not expensive to generate the analog,” Pham said.
“In this way the drug can be breathed in and delivered to the brain,” he said, noting that nebulizers are out in the market already, and are relatively inexpensive.
“In this paper we also showed that delivery to the cortex and hippocampal areas is more efficient using aerosolized curcumin than intravenous injection in a transgenic mouse model of Alzheimer’s disease,” Pham said.